This study sought to determine the efficacy of atis (Annona squamosa) and lemongrass (Cymbopogon stratus) leaves and sensory evaluation of atis and lemongrass leaves by ten (10) CHMT faculty members and ten (10) CTE students majoring in Science at Laguna State Polytechnic University and ten (10) housewives of Barangay Bagumbayan Lynnville Subdivision, Santa Cruz, Laguna and considered the result as a basis for acceptability of atis and lemongrass leaves as mosquito repellent. In particular, it described the methods of preparing atis and lemongrass and their level of acceptability as to sensory qualities such as appearance, aroma, color, and solubility. It also ascertained the significant difference between the level of acceptability of atis and lemongrass based on the sensory qualities as rated by the three sets of respondents as to faculty, students, and housewives. Using the experimental research method, a series of evaluation and taste tests using scorecards were distributed to three groups of randomly selected respondents. Mean, standard deviation, and t-tests were also used to analyze the statistical data gathered in the study. It was revealed that atis and lemongrass leaves as mosquito liquid repellent have a highly acceptable appearance, aroma, color, and solubility. Further, there is a significant difference in the level of acceptability between the students and faculty members, but there is no significant difference between the students and housewives. Thus, a new product was developed and evaluated as highly acceptable in all its parameters. The atis and lemongrass leaves as mosquito liquid repellent were accepted and assessed by housewives, faculty, and students who must enhance their creativity to create products that serve as a great reservoir for insect-causing diseases.