Biology and Life Sciences
Publisher Name: IJRP
Views: 387 , Download: 90 , Pages: 202 - 209
DOI: 10.47119/IJRP1001571920247206
Authors
# | Author Name |
---|---|
1 | ADEBO AUGUSTINA OFURE |
2 | AMA-IRUOBE PRECIOUS IRUEBAFA |
3 | ERHABOR AISOSA PRINCE |
4 | OGBETA TAYE SUNDAY |
Abstract
This study evaluated the anti-ulcerative potentials of Turmeric (Curcuma longa) extract on gastric ulcer induced by alcohol, potash and their combination. The study was an experimental study using Wistar rats as a model. We used thirty adult Wistar rats for the experimentation and were assigned into five groups, namely A1, A2, B, C, and D and each group had 6 animals each. Group A1 and A2 were the positive controls for alcohol and potash induced ulcers respectively while groups B, C, and D, served as the test groups, where ulcer was induced using alcohol, potash and their combination respectively, and subsequently treated with turmeric extract. Following induction of gastric ulcer, treatment using turmeric extract was administered 3 hours later and this continued for one week. The results showed reduced mean ulcer scores in the test groups (B= 1.25±0.01, C= 1.30±0.85, D= 2.03±0.11) compared to control (A1= 3.09±00.0, A2= 2.07±0.22) while mean percentage inhibition rate in the treated groups (B= 4.32+00.48, C= 1.09+00.01, D= 2.01+00.66) was lower compared to control (A1= 5.04±00.12 and A2= 2.08±01.00). Although the differences were not statistically significant (p < 0.05), they however revealed, in this study, an anti-ulcer attribute to the phytochemicals of turmeric extract. Further studies on this extract are strongly suggested.