The acyl-CoA dehydrogenase short chain is the genes which are found in the mitochondria of the cells, expressed in various tissues in the body. The enzymes which produced from these genes have a role to catalyze the foremost step of the mitochondrial fatty acid beta-oxidation pathway which is an important process in making the FADH2 and NADH, for the cellular respiration. Lacking ACADS genes might lead to the cells unavailable to produce ATPs in the mitochondria, and as these genes are also found in the cardiac tissues of the human body, this review papers will assess the extent in which the ACADS genes affect the risk of developing heart disease.