Biology and Life Sciences

Biology and Life Sciences


Pages: 14  ,  Volume: 5  ,  Issue: 2 , May   2018
Received: 01 Jun 2018  ,  Published: 03 June 2018
Views: 92  ,  Download: 44


# Author Name
1 Simanchal Panda
2 Dr. S.R. Mishra


ABSTRACT: Caffeine is an xantheine derivative mild CNS activity largly found in Cofee Cafea Arabica , tea Thea sinsensis , which is the largest consumed drink after water in the world. Here the research work is an attempt to mask mouth dissolving caffeine tablet which is an anti psychotic drug and analgesic with antihypertensive and diuretic drug. The caffeine was extracted by the following method. First the leaves of coffee and fruit pulp, seeds were collected from medicinal/ herbal garden of Jeypore College of Pharmacy, which was confirmed by Swaminathan Research centre, Jeypore , as Cofea Arabica plant. It was percolated in hot water overnights and filtered . The collected sample was placed in separated funnel and added chloroform. After swirling it was stood for time till two phases separated and the chloroform was collected and evaporated till caffeine was found in crystal form. Micromeritics study of pure drug measured by tapped density, bulk density, angle of repose, carr’s index , hausner’s ratio which found to be 0.1742,0.2632,33.82%,1.52,33.52 respectively. Superdisintegrants such as sodium starch glycolate was used to optimized. Different binders were uded along with optimized superdisintegrant concentration. The tablets were prepared by direct compression technique. The tablets were evaluated for hardness, friability, weight variation, wetting time, disintegration time, and uniformity of content. Optimized formulation was evaluated by in vitro dissolution test.


  • dissolution
  • mouth dissolving tablets
  • disintegration
  • superdisintegrant
  • tablet evaluations
  • References

    [1] A REVIEW ON CAFFEINATED TOOTHPASTE Simanchal Panda*, Monalisa Nayak and Sarala Nayak Jeypore College of Pharmacy, Rondapalli, Jeypore (K), 764001 WORLD JOURNAL OF PHARMACY AND PHARMACEUTICAL SCIENCES Volume 7, Issue 1. [2] The impact of coffee on health A. Cano-Marquina a J.J. Tarínb A. Cano [3] THE MICROSCOPY OF THE COFFEE FRUIT 1MB701.html [4] THE BOTANY OF THE COFFEE PLANT [5] FORMULATION AND EVALUATION OF TOOTHPASTE BY USING EGGSHELLS Gaurav Balu Dafal* and Navin K. Khare Department of Pharmaceutics, Dr. D.Y.Patil Institute of Pharmaceutical Science and Research, Pimpri, Pune,Maharashatra, India, 411018. [6] American pharmaceutical association. [7] S. A. Sreenivas, P. M. Dandagi, A. P. Gadad et al., “Orodispersible tablet: new-fanged drug delivery system—a review,” Indian Journal of Pharmaceutical Education and Research, vol. 39, no. 4, pp. 177–181, 2005.  [8] D. Bhowmik, B. Chiranjib, K. Pankaj, and M. R. Chandira, “Fast dissolving tablet: an overview,” Journal of Chemical and Pharmaceutical Research, vol. 1, no. 1, pp. 163–177, 2009.  [9] B. G. Prajapati and N. Ratnakar, “A review on recent patents on fast dissolving drug delivery system,” International Journal of PharmTech Research, vol. 1, no. 3, pp. 790–798, 2009.  [10] M. Swamivelmanickam, R. Manavalan, and K. Valliappan, “Mouth dissolving tablets: an overview,” International Journal of Pharmaceutical Sciences and Research, vol. 1, no. 12, pp. 43–55, 2010. [11]K. D. Tripathi, Essential of Medical Pharmacology, pp. 216–217, Jaypee Brothers Medical, New Delhi, India, 6th edition, 2008. [12]S. B. Jadhav, D. R. Kaudewar, G. S. Kaminwar, A. B. Jadhav, R. V. Kshirsagar, and D. M. Sakarkar, “Formulation and evaluation of dispersible tablets of diltiazem hydrochloride,” International Journal of PharmTech Research, vol. 3, no. 3, pp. 1314–1321, 2011.  [13] V. Metker, A. Kumar, N. Pathak, K. Padhee, and S. Sahoo, “Formulation and evaluation of orodispersible tablets of lornoxicam,” International Journal of Drug Development and Research, vol. 3, no. 1, pp. 281–285, 2011.  [14] A. Arya, S. Sharma, J. Kumar, A. Chandra, and P. Jaiswal, “Formulation and evaluation of mouth dissolving tablets of ranitidine HCL,” International Journal of Pharm Tech Research, vol. 2, no. 2, pp. 1574–1577, 2010.  [15] R. B. Parmar, A. H. Baria, H. M. Tank, and S. D. Faldu, “Formulation and evaluation of domperidone fast dissolving tablets,” International Journal of PharmTech Research, vol. 1, no. 3, pp. 483–487, 2009.  [16] B. Senthilnathan and A. Rupenagunta, “Formulation development and evaluation of venlafaxine hydrochloride orodispersible tablets,” International Journal of Pharmaceutical Sciences and Research, vol. 2, no. 4, pp. 913–921, 2011.  P. B. Anjankumar, M. Nazmuddin, U. Kulkarni, and R. C. Hariprasanna, “Formulation and evaluation of lornoxicam fast dissolving tablet,” International Research Journal of Pharmacy, vol. 2, no. 4, pp. 130–133, 2011.  [18] N. C. Mohire and A. V. Yadav, “Novel approach to formulate ?-cyclodextrin complexed mouth dissolving tablet of metronidazole and its in-vitro evaluation,” Journal of Pharmacy Research, vol. 3, no. 3, pp. 662–667, 2010.  [19] ICH Harmonised Tripartite Guideline. Cover Note for Revision of Q1A(R) Stability Testing of New Drug Substances and Products.Q1A (R2): pp. 9. [20] [21] Ammar, H A salma, M Ghorab, Formulation and biological evaluation of cyclodextrin- polymer systems, Int J Pharm, 2006; 309: 129. [22] Pharmaceutical dosage forms: Tablets, Vol-1, Second edition, Revised and Expanded Lieberman, Lachman & Schwartz. [23] Jens T. Cartensen; Drug Stability principles and Practices, 1990; 394-399.