Biology and Life Sciences

Biology and Life Sciences

FORMULATION AND EVALUATION OF MOUTHDISSOLVING TABLETS FROM EXTRACTED CAFFEINE

Pages: 14  ,  Volume: 5  ,  Issue: 2 , May   2018
Received: 01 Jun 2018  ,  Published: 03 June 2018
Views: 92  ,  Download: 44

Authors

# Author Name
1 Simanchal Panda
2 Dr. S.R. Mishra

Abstract

ABSTRACT: Caffeine is an xantheine derivative mild CNS activity largly found in Cofee Cafea Arabica , tea Thea sinsensis , which is the largest consumed drink after water in the world. Here the research work is an attempt to mask mouth dissolving caffeine tablet which is an anti psychotic drug and analgesic with antihypertensive and diuretic drug. The caffeine was extracted by the following method. First the leaves of coffee and fruit pulp, seeds were collected from medicinal/ herbal garden of Jeypore College of Pharmacy, which was confirmed by Swaminathan Research centre, Jeypore , as Cofea Arabica plant. It was percolated in hot water overnights and filtered . The collected sample was placed in separated funnel and added chloroform. After swirling it was stood for time till two phases separated and the chloroform was collected and evaporated till caffeine was found in crystal form. Micromeritics study of pure drug measured by tapped density, bulk density, angle of repose, carr’s index , hausner’s ratio which found to be 0.1742,0.2632,33.82%,1.52,33.52 respectively. Superdisintegrants such as sodium starch glycolate was used to optimized. Different binders were uded along with optimized superdisintegrant concentration. The tablets were prepared by direct compression technique. The tablets were evaluated for hardness, friability, weight variation, wetting time, disintegration time, and uniformity of content. Optimized formulation was evaluated by in vitro dissolution test.

Keywords

  • dissolution
  • mouth dissolving tablets
  • disintegration
  • superdisintegrant
  • tablet evaluations
  • References

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