Background: Astrocytoma is a neuroepithelial tumor of glial cells consisting of infiltrative tumor cells with increased cellularity in accordance with histopathology grade. Vascular Endothelial Growth factor (VEGF) is one of the important factors in the process of angiogenesis. VEGF plays a role in proliferation, survival, endothelial cell migration and vascular permeability.
Materials and methods: This study is an analytical study with cross-sectional approach with spearman test analysis of 31 samples of paraffin blocks of astrocytoma cases that meet the inclusion criteria then immunohistochemistry examination with VEGF and assessed VEGF expression that will be correlation with histopathology grade of astrocytoma.  
Results: A total of 31 samples showed VEGF expression, 7 cases were astrocytoma grade I, 11 cases were astrocytoma grade II, 5 cases were astrocytoma grade III and 8 cases were grade IV astrocytoma. Statistical analysis has a correlation between VEGF expression with histopathology grade of astrocytoma p = 0.005 (p<0.05) and shows a sufficient relationship with r = 0.448. Conclusions: This study revealed that increased VEGF expression was followed by histopathology grade of astrocytoma.  
Conclusion:   There is a correlation between the immunohistochemistry expression of VEGF  and histopathology grade of astrocytoma, where the increase in VEGF expression is followed by an increase in histopathology grade of astrocytoma                                                                           
Keywords: Astrocytic tumours, Grade histopathology, VEGF