ABSTRACT

Background: Background: MUC1 has become a topic of concern in cancer treatment because of its upregulation which might influence the invasion, proliferation, and survival of tumor cells by reducing cell adhesion and extracellular cell-matrix adhesion. Besides, stray overexpression from MUC1 is associated with angiogenesis and chemoresistance in cancer. Thus MUC1 has a role in tumorigenesis, progressive and metastasis, this can function as an underlying prognostic factor. An accurate biomarker for early diagnosis and a more accurate prognosis can improve the efficiency of current treatment in breast cancer and is a molecular marker for target therapy.

Objective: To evaluate the MUC1 immunohistochemistry characteristics and expression in invasive breast carcinoma.

Materials and Methods: A descriptive study with a cross-sectional approach, using tissue paraffin blocks from 42 patients with invasive breast carcinoma and given a MUC1 immunohistochemistry appearance, then a broad percentage of MUC1 expression was assessed.

Results: MUC1 immunohistochemistry expression in invasive breast carcinoma was mostly positive (76.2%). Based on the involvement of MUC1 immunohistochemistry expression based on the presence or absence of distant invasive breast carcinoma found in M1 the highest shows positive MUC1 expression (100%). Immunohistochemistry expression of MUC1 based on histopathological grading was obtained at the highest grade 3 showing positive MUC1 expression (93.8%). Immunoreactivity patterns of MUC1 expression found the most diffuse cytoplasmic patterns (26.2%).

Conclusion: The presence of distant metastases tends to show high positive MUC1 expression and there is also a tendency that if a histopathological grading is high then it will show that MUC1 expression is also highly expressed

Keywords: invasive breast carcinoma, MUC1 immunohistochemistry  expression, distant metastasis, histopathological grading