Non-alcoholic fatty liver disease (NAFLD) is a major public health issue, impacting millions and leading to complications like liver cirrhosis and cardiovascular disease. As NAFLD prevalence increases, understanding the factors that affect the quality of life (QoL) of those affected is vital. While research has identified the roles of social support, health literacy, and coping strategies in influencing QoL, significant gaps remain in understanding their interactions and relative contributions. Addressing these gaps is essential for developing effective interventions to improve the well-being of individuals with NAFLD. The research adopts a descriptive correlational design to explore the relationship between the identified predictors and the quality of life of NAFLD patients. Correlation analysis was employed to examine the relationships between health literacy, family support, coping strategies, and quality of life across all domains. The analysis found a significant negative correlation between quality of life and health literacy (τ = -0.2036, **p < 0.01), indicating that higher health literacy is associated with better quality of life, while family support showed a weak, non-significant correlation (τ = -0.0102). Additionally, a significant negative correlation between health literacy and family support (τ = -0.1792, **p < 0.01) suggests that increased health literacy may be linked to lower perceptions of family support. The study emphasizes the need for tailored education and interventions, as well as family engagement in treatment plans, to improve patient outcomes and quality of life in managing NAFLD.

Predictor

Coping strategies

Health Literacy

Family social support

Quality of Life

Non-alcoholic Fatty Liver Disease (NAFLD)