Background: Graves disease is an autoimmune disorder that is the primary trigger for excessive thyroid hormone secretion. It has three main clinical characteristics: enlargement of the thyroid gland, protrusion of the eyes (ophthalmopathy), and skin lesions (dermopathy). Laboratory examination typically reveals decreased TSH, increased FT3 and FT4, and elevated TSH receptor antibodies (TRAb). Objective: To evaluate the clinical and laboratory profiles, as well as the anatomical pathology of Graves disease patients at Dr. Soetomo General Hospital from January 2016 to December 2020. Methods: This retrospective observational study utilized the medical records of Graves disease patients at the Integrated Endocrinology Service and Anatomical Pathology Laboratory of Dr. Soetomo General Hospital, spanning from January 2016 to December 2020. The study evaluated patient profiles including age, gender, chief complaint, vital signs, TSH, FT4, total T3, total T4 levels, radiological features, anatomical pathology findings, and treatments administered. Results: Data from Dr. Soetomo General Hospital in Surabaya showed 172 Graves disease patients from January 2016 to December 2020. The majority were female (76.2%) and aged 31-40 years (32%), with the most common complaint being palpitations (53.5%). Most patients had normal temperature, respiratory rate, and pulse, but were prehypertensive. TSH levels were below normal in 83.3% of patients, while FT4, total T3, and total T4 levels were above normal in 59.1%, 57.8%, and 50% of patients, respectively. Radiological imaging showed hyperthyroidism in 87 patients, with diffuse goiter being the most common feature. Anatomical pathology examinations in 42 patients revealed nodular colloid goiter in 24 patients. The majority of patients (76.2%) were treated with thiamazole and propranolol. Conclusion: The diagnosis of Graves disease can be made based on patient history, clinical symptoms, physical examination, and laboratory tests. Radiological and anatomical pathology examinations can be used as additional evaluations.  

GRAVES DISEASE

CLINICOPATHOLOGICAL PROFILE