Coronavirus Disease 2019 (COVID-19) is an infectious disease caused by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2). COVID-19 infection triggers an inflammatory response characterized by an increase in Neutrophil-Lymphocyte Ratio (NLR) and C-Reactive Protein (CRP). This study aims to determine the relationship between NLR and CRP levels and the severity of COVID-19 patients treated at Haji Adam Malik General Hospital in Medan. This study is a retrospective observational analytic study with a cross-sectional design, conducted at Haji Adam Malik General Hospital in Medan from January 1 to December 1, 2022. The study sample included all patients aged 18 years and above who were treated in the COVID-19 isolation ward at Haji Adam Malik General Hospital, tested positive for COVID-19 via PCR swab, and underwent NLR and CRP examinations upon their initial admission to the hospital. A total of 98 patients tested positive for COVID-19 via PCR swab, with 49 cases of moderate severity, 32 cases of severe severity, and 17 cases of mild severity. The increase in NLR and CRP was significantly associated with the severity of COVID-19 (p < 0.001). Comorbid conditions such as diabetes mellitus and chronic kidney disease were not associated with increases in NLR and CRP (p > 0.005). Patients with a history of vaccination showed a significant increase in NLR (p = 0.01) and CRP (p = 0.001).

COVID 19

Infection

NLR

CRP