This research aims to apply a mathematical model to analyze the optimal location of logistics operators distribution centers in Thailand by applying the mathematical model called Center of Gravity Technique. The model used cost information in the transportation system, which came from the lowest cost of the operators and the needs of logistics service users based on data from the 9 provinces with the highest volume of logistics services, namely Nakhon Sawan, Chiang Mai, Ubon Ratchathani, Khon Kaen, Nakhon Ratchasima, Kanchanaburi, Surat Thani, Phuket and Chonburi to analyze. In addition, qualitative factors were also taken into account, namely proper location and environment. The results showed when the Center of Gravity Technique was applied to the data of logistics operators in the 9 provinces with the volume of customer demand in 2017-2018 together with the analysis of the location and environment, there was only one location for the center of aggregate demand and supply. The suitable area for the distribution center was located at 14.44948283, 101.06126328 or 14° 26 58.1 N 101° 3 40.5 E or UTM 722200.217 East(X) 1598435.446 North(Y) Zone 47 Band P, which is the coordinates of Tha Maprang subdistrict, Kaeng Khoi district, Saraburi province because there were product resources, transportation routes, qualified and sufficient work resources, good attitudes of people, public services and environment in the area.