Medicine, Health & Food
Volume: 149 , Issue: 1 , May Published Date: 19 May 2024
Publisher Name: IJRP
Views: 176 , Download: 189 , Pages: 84 - 90
DOI: 10.47119/IJRP1001491520246497
Publisher Name: IJRP
Views: 176 , Download: 189 , Pages: 84 - 90
DOI: 10.47119/IJRP1001491520246497
Authors
# | Author Name |
---|---|
1 | Muhammad Ibnu Kaesar Purba |
2 | Frank Bietra Buchari |
3 | Utama Abdi Tarigan |
4 | Lia Kusumawati Iswara |
5 | Eliza Nindita |
Abstract
Introduction: Burns lead to significant morbidity due to infection risks. This study compares the effectiveness of petroleum jelly silver sulfadiazine and a combination of hyaluronic acid with silver sulfadiazine on bacterial growth common in burn infections in vitro. Methods: An in vitro experimental design was utilized, involving cultures of Pseudomonas aeruginosa, Acinetobacter baumannii, and Staphylococcus aureus. The study assessed the inhibitory effects of the treatments on bacterial growth using the Kirby-Bauer disk diffusion method. Results: Results indicated varying levels of bacterial growth inhibition by the treatments, with significant differences observed between the treatments effectiveness on gram-positive and gram-negative bacteria. The combination of hyaluronic acid and silver sulfadiazine showed superior inhibitory effects on gram-positive bacteria, while silver sulfadiazine alone was more effective against gram-negative bacteria. Discussion: The study suggests the importance of treatment selection based on bacterial type in burn infections. The combination of hyaluronic acid and silver sulfadiazine may offer a better therapeutic option for gram-positive bacterial infections, highlighting the need for targeted antimicrobial strategies.