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COMPARISON OF THE EFFECTIVENESS OF VARIOUS TOPICAL TREATMENT ON THE GROWTH OF BACTERIA IN BURNS INFECTION IN VITRO

Volume: 149  ,  Issue: 1 , May    Published Date: 19 May 2024
Publisher Name: IJRP
Views: 176  ,  Download: 189 , Pages: 84 - 90    
DOI: 10.47119/IJRP1001491520246497

Authors

# Author Name
1 Muhammad Ibnu Kaesar Purba
2 Frank Bietra Buchari
3 Utama Abdi Tarigan
4 Lia Kusumawati Iswara
5 Eliza Nindita

Abstract

Introduction: Burns lead to significant morbidity due to infection risks. This study compares the effectiveness of petroleum jelly silver sulfadiazine and a combination of hyaluronic acid with silver sulfadiazine on bacterial growth common in burn infections in vitro. Methods: An in vitro experimental design was utilized, involving cultures of Pseudomonas aeruginosa, Acinetobacter baumannii, and Staphylococcus aureus. The study assessed the inhibitory effects of the treatments on bacterial growth using the Kirby-Bauer disk diffusion method. Results: Results indicated varying levels of bacterial growth inhibition by the treatments, with significant differences observed between the treatments effectiveness on gram-positive and gram-negative bacteria. The combination of hyaluronic acid and silver sulfadiazine showed superior inhibitory effects on gram-positive bacteria, while silver sulfadiazine alone was more effective against gram-negative bacteria. Discussion: The study suggests the importance of treatment selection based on bacterial type in burn infections. The combination of hyaluronic acid and silver sulfadiazine may offer a better therapeutic option for gram-positive bacterial infections, highlighting the need for targeted antimicrobial strategies.

Keywords

  • burn infections
  • bacterial growth
  • petroleum jelly
  • silver sulfadiazine