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The Relationship Between Carcinoembryonic Antigen (CEA) and The Severity Risk of Colorectal Adenocarcinoma Grading

Volume: 139  ,  Issue: 1 , December    Published Date: 30 December 2023
Publisher Name: IJRP
Views: 293  ,  Download: 247 , Pages: 308 - 313    
DOI: 10.47119/IJRP10013911220235896

Authors

# Author Name
1 Gusti Ayu Laksmi Dewi Saputri
2 Ketut Sudartana
3 I Made Mulyawan

Abstract

Colorectal carcinoma is the third most common malignancy among all carcinoma patients. Carcinoembryonic antigen (CEA) is used as a tumor marker for colorectal carcinoma patients as it is inexpensive, easily measured through serum tests, and can be repeated multiple times with minimal impact, however its use in the risk of colorectal adenocarcinoma is unclear. We aimed to investigate the relationship between CEA levels and the severity risk of grading in colorectal adenocarcinoma patients. There is a significant relationship between grading and CEA, namely, the higher the CEA, the worse the grading becomes. No significant difference was found between the CEA values in different grades, but the average value increases as the grading of colorectal carcinoma worsens. A CEA value of 8.45 serves as the cut-off point for worse differentiation, with a sensitivity of 61.8% and a specificity of 65.2%.

Keywords

  • Colorectal carcinoma
  • colorectal adenocarcinoma
  • carcinoembryonic antigen
  • CEA