Chronic Kidney Disease (CKD) is a serious disease in children with increasing prevalens over the years. Sustained pain and uncertainty for recovery mostly leads to certain mental condition, such as depression and anxiety. This condition also usually affected the caregiver for children with CKD. This study will discuss about the quality of life of children with CKD. The aim of this systematic review is to determine quality of life of children with CKD and factors associated with quality of life of children with CKD.There are 4 studies used for this systematic review study and was conducted through PubMed database. The number of inclusion studies that will be discussed in this study consists of 2 cross-sectional studies, 1 case controls, and 1 descriptive-analytic. A total of 224 children with CKD were involved in all inclusion studies of this study. The results of the analysis of all included studies in this study showed that patients with CKD were found to have impaired quality of life. Children with CKD scored lower than controls on all subscales. ESRD was related to significant morbidity and a poorer QOL. Risk factors for impaired quality of life are age 5-7 years, age 13-18 years, low socioeconomic status, father with low education level, and use of steroids. Children with CKD have impaired quality of life (QoL). Children with CKD have lower quality of life than controls on all subscales in terms of physical, emotional, social, and schooling. The risk factors for decreased quality of life (QoL) in children with CKD are the child's age, low socioeconomic and parental education levels, unexpected parenting patterns, length of illness, and use of steroids.