ABSTRACT

Background: Lung cancer most often causes malignant pleural effusion and the most common type is adenocarcinoma. Metastastasis of breast, gastrointestinal and genitalia tumors is also a frequent cause of pleural effusion through lymphatic spread and it is important to observe the dominant cytomorphological picture of pleural effusion in adenocarcinoma metastasis.

Objective: To determine the cytomorphology of adenocarcinoma metastasis in pleural effusion fluid

Material and Methods: Cytomorphological observations were performed on pleural effusion cytology slides consisting of 36 samples to determine the dominant cytomorphology. All characteristic data are obtained through medical records and pathology archives. Statistical analysis is descriptive with cross sectional approach.

Result: Most of the patient were diagnosed at the age of 55-64 years with female dominance and the origin of all metastases from lung adenocarcinoma. The most common cytomorphology of  long adenocarcinoma metastasis in pleural effusion fluid is the hyperchromatic nucleus, pleomorphic nucleus and increased N/C ratio and subsequent sequences are irregular core membrane, macronucleoli, acinar, perinuclear vacuolation, cell ball, binucleated, uniform cell population, eccentric nucleus, papillary formation, berry countour and the least is cell in cell.

Conclusion: The results of this study have various similarities with previous studies, but further examination and research are needed for better results.

Keywords: Pleura effusion, adenocarcinoma, pulmonary adenocarcinoma, cytomorphology