Medicine, Health & Food
Volume: 118 , Issue: 1 , February Published Date: 03 February 2023
Publisher Name: IJRP
Views: 682 , Download: 407 , Pages: 14 - 21
DOI: 10.47119/IJRP1001181220234449
Publisher Name: IJRP
Views: 682 , Download: 407 , Pages: 14 - 21
DOI: 10.47119/IJRP1001181220234449
Authors
| # | Author Name |
|---|---|
| 1 | Brigitta |
| 2 | I Wayan Weta |
| 3 | I Gusti Ayu Artini |
Abstract
Background: The hair aging process also known as senile alopecia occurs follicle miniaturization, shortening of the anagen phase and increasing proportion of hair in the telogen phase which results in hair loss and hair thinning. Rice bran oil contains ϒ-Oryzanol which has the effectiveness as the natural antioxidant to increase hair growth. Tochopherol, policosanol, γ-linolenic acid, linoleic acid, and oleic acid have been shown to have role in inhibiting 5α-reductase enzymes, increasing hair growth factors such as VEGF and reduce inflammation. Method: This study was an experimental analytic research post-test only control group design that was perform at Faculty of Medicine, Udayana University. This study used 30 Wistar male rats (Rattus norvegicus) and divided into three groups: Negative control group with administration of paraffin oil (P), positive control group with administration of 2% minoxidil (M), and treatment group with administration of 100% rice bran oil (R) for 21 days. Results: there was a significant difference in VEGF levels between the M (153.49 ± 1.7 ng/L) and P (85.5 ± 1.88 ng/L) (p < 0.001), and R (152.25 ±0.94 ng/L) and P (p<0.001), but there was no difference between the M and R groups (p=0.088). There was a significant difference in hair follicle diameter between the M (10.7±4.87 µm) and P (5.73±2.18 µm) (p= 0.030) and R (9.72±319 µm) and P (p=0.013). However, there was no difference in hair follicle diameter between the M and R (p = 0.857). There was a significant difference in hair length between the M (12.02±2.09 mm) and P (7.53±1.12 mm) (p <0.001) and R (13.12±2.14 mm) and P (p < 0.001). However, there was no difference in hair length between the M and R (p = 0.495). Conclusion: Rice bran oil has the same effect with 2% topical minoxidil as a gold standard to prevent senile alopecia through improved VEGF protein expression, the follicle diameter and hair length of wistar rat that were induced to ultraviolet B. The results of this study are expected to be used as a reference for further research.