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Association of Serum Uric Acid with Severity of Ischemic Stroke

Volume: 116  ,  Issue: 1 , January    Published Date: 10 January 2023
Publisher Name: IJRP
Views: 54  ,  Download: 23 , Pages: 261 - 268    
DOI: 10.47119/IJRP1001161120234421

Authors

# Author Name
1 Muhammad Fadhila Naufal
2 Mohammad Saiful Ardhi
3 Ulfa Kholili
4 Achmad Firdaus Sani

Abstract

Serum Uric Acid (SUA) is the end product of nucleotide metabolism. The level of SUA is increased (hyperuricemia) when the balance between the production, for example in people with purine-rich diet, and the disposal of uric acid is disrupted, such as those with kidney problems. Studies found conflicting result about its association with stroke, particularly ischemic stroke (IS). The study aims to determine the relationship between SUA and severity of ischemic stroke patients, measured with the National Institute of Health Stroke Scale (NIHSS). This research is a correlational study, and a retrospective cross-sectional study by collecting data from medical records of IS patient in Dr. Soetomo General Hospital Surabaya within the period of January 2019 – December 2019. SUA level is taken from the medical records filled at admission. The severity of stroke is measured using NIHSS data obtained during the beginning of the hospital admission. 41 out of 51 patients met the inclusion criteria. The data is analyzed using the Spearman Rank correlation test to determine the relationship between SUA and severity of ischemic stroke. The result showed no significant correlation (p=0.897) with a very weak correlation value of 0.021. The limitation of this study is that it was a single-centered study with a small number of sample limiting its generality. Additional researches with bigger subjects are needed to study about the association of SUA and stroke severity.

Keywords

  • Uric acid
  • ischemic stroke
  • stroke severity
  • NIHSS