Systemic Lupus Erythematosus is a chronic autoimmune disease that affects multiple organs and has variations of clinical manifestations due to the involvement of multiple autoantibodies, immune complex formation and deposition, and immune processes. Previous studies suggested an increased risk of osteoporosis in systemic lupus erythematosus patients according to bone mineral density (BMD) values. This literature study aims to describe the definition of bone mineral density and systemic lupus erythematosus, the bone mineral density of systemic lupus erythematosus, and the risks of osteoporosis in systemic lupus erythematosus patients.