Background: Based to the National Spinal Cord Injury Statistical Center (NSCISC) of the University of Alabama at Birmingham, USA, there are 15 to 40 cases of Spinal Cord Injury (SCI) per one million population each year (approximately 4,125 to 11,000 new cases) in the world. Neutrophils in SCI have two roles, namely beneficial and detrimental. These roles can be an outcome indicator in Traumatic Spinal Cord Injury, especially in the acute phase of SCI. Therefore, this study aimed to analyze neutrophils role in SCI outcome indicators. Methods: This systematic review used secondary data in the form of animal trial studies that were found in the last five years. Five databases were searched, including PubMed, Science Direct, Scopus, Web of Science, and Springer Link, using keywords spinal cord injury, neutrophil, inflammation, and outcome. Results: There were six studies reviewed in which all studies explained the detrimental role of neutrophils in SCI. Five studies explained that the role could be inhibited by proinflammatory cytokines and chemokines, while four studies explained an increase in locomotor function after observation until the remodeling phase. Conclusion: The dominant role of neutrophils in SCI is detrimental. This role can be affected by two factors that become resolutions: direct and indirect. These two factors also affect the improvement in the locomotor function of SCI.

Neutrophil

Spinal Cord Injury

Locomotor

Beneficial

Detrimental