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DIFFERENCES PLATELET INDICES IN HYPOPROLIFERATIVE AND HYPERDESTRUCTIVE THROMBOCYTOPENIA

Volume: 114  ,  Issue: 1 , December    Published Date: 04 December 2022
Publisher Name: IJRP
Views: 508  ,  Download: 351 , Pages: 75 - 81    
DOI: 10.47119/IJRP10011411220224178

Authors

# Author Name
1 Andy Sudjadi
2 Leni Lismayanti
3 Agnes Rengga Indrati

Abstract

Thrombocytopenia can increase the risk of bleeding. Determination of the type of thrombocytopenia is important because it will affect patients treatment. The gold standard for distinguishing types of thrombocytopenia is bone marrow examination. This examination is invasive and carries risk of bleeding. Platelet indices are simple and less invasive and reliable in distinguishing the types of thrombocytopenia. The aim of this study is to evaluate the value of the platelet indices in differentiating types of thrombocytopenia.This study used retrospective cross sectional study. Subjects with leukemia, aplastic anemia, MDS for hypoproliferative thrombocytopenia (group 1), dengue fever, ITP, Evans syndrome, sepsis, pneumonia, and typhoid fever for hyperdestructive thrombocytopenia (group 2). Inclusion criteria were the subjects data with a platelet count <100,000 with data with name, age, sex, diagnosis and platelet count, PCT, MPV, PDW. Group 1 consisted of 103/150 (68.67%) subjects and group 2 47/150 31.33%) subjects. Platelet indices in group 1 vs group 2, MPV 10,02  0,85 vs 11,72  1,11  (p = 0,017) PDW 10,0 (7 – 15,70) vs 14,5 (10,40 – 19,40) (p  <0,001) dan PCT 0,04 (0,01 – 0,19) vs 0.06 (0,01 – 0,10) (p = 0,208) Thrombocyte count 41 (11-97) vs 50 (8-90) (p = 0,380). MPV, PDW values were higher in  hyperdestructive thrombocytopenia, because there was no thrombopoiesis abnormality in bone marrow to produce young platelets. PCT difference was not significant because platelet count was not significantly different and MPV was little significant. MPV and PDW values can differentiate types of  thrombocytopenia.

Keywords

  • platelet index
  • thrombocytopenia
  • hyperdestructive
  • hypoproliferative