Approximately 10-15% of COVID-19 patients will progress to severe cases and require treatment in the ICU. One of the laboratory tests used in monitoring patients in the ICU is D-dimer. Elevated levels of D-dimer can predict the disease severity and mortality. This study aimed to analyze the relationship between D-dimer levels and the length of ICU stay of the COVID-19 patients. This was an analytic observational study using a cross-sectional design with a retrospective approach. The secondary data were in the form of confirmed COVID-19 patients at Dr. Soetomo General Hospital Surabaya from April 2020 to March 2021. The correlation was determined using the Spearmans Rank Correlation Coefficient test. Based on the criteria, it was obtained a sample of 120 patients with the median of initial D-dimer 2225 (855 – 6122.5) ng/mL FEU and the median duration of the ICU stay 9 (1 – 32) days. The result of the comparative analysis of the initial D-dimer levels on clinical outcomes indicated a p-value of 0.012. Patients with life clinical outcomes showed a relationship between initial D-dimer levels and the length of ICU stay (p = 0.328 (r2) = 0.309) while in patients with death clinical outcomes was (p =0.023 (r2) = -0.219). Elevated D-dimer levels as a marker of thrombosis were reported. The increase in D-dimer levels were correlated with mortality. There was a correlation between initial D-dimer levels and length of ICU stay in COVID-19 patients with death clinical outcome.

ICU stay

D-dimer

COVID-19