Backgrounds: In hyperglycemia induced by streptozotocin, free radicals and oxidative stress conditions occur. This also reduced SOD enzymes while increasing CRP. This study aimed to analyze effect of flavonoid-rich taro leaves ethanol extract on SOD levels and serum CRP levels in rats diabetes melitus model induced by streptozotocin. Methods: Experimental study with a pretest-posttest control group design 26 healthy rats were randomly divided into 2 groups. The control group was given 2 ml aquadest and treatment group was given 400mg/kgBW ethanol extract of taro leaves in 2 ml aquadest. Before and after treatment, blood serum was collected for SOD and CRP analysis using the ELISA technique. Results: SOD level in control goup before and after given plasebo were reduce insignificantly (from 5.37?0.69 ng/ml to 5.26?1.50 ng/ml ;p = 0.830). Furthermore, CRP level in control group before and after given plasebo were not signifcantly different (from 3.39?0.24 ng/ml to 3.56 ?0.43 ng/ml ; p = 0.308). SOD level in treatment group before and after given taro extract were increase but not significant (from 5.33 ?1.14 ng/ml to 6.20 ?2.64 ng/mL; p = 0.239). However, CRP level in control group after given plasebo decrease significantly (from 3.56 ? 0.43 ng/mL to 2.93 ? 0.47 nmol/mL ; p = 0.009).Conclusion: ethanol extract of taro leaves did not increase SOD levels but decrease CRP levels in rats model diabetes melitus induced by streptozotocin. Further studies are needed to confirm extract of taro leaves as external antioxidant.

CRP

Diabetes mellitus

SOD

Streptozotocin

Taro leaves