Background: The Cancer Genome Atlas combines gene characteristics and identifies four groups of endometrial carcinoma, one of them is P53 mutations which are associated with poor prognosis. MMP-9 is one of the most widely observed types of MMPs to play an important role in cancer cell invasion and tumor metastasis. Tumor budding is defined as a single cell or cluster of cells consisting of < 5 cells, located at the edge of the invasive tumor front. There are relationship between tumor budding and the epithelial mesenchymal transition (EMT). The EMT process is characterized by an increase in matrix metalloproteinases that play a role in the degradation of the extracellular matrix and basement membrane, which is the process of invasion and metastasis. Methods: This is an analytical study with cross sectional approach on 38 resection specimens from the patients diagnosed as endometrial carcinoma. The statistical analysis was performed by using Chi-square test to analyze the correlation of the correlation of expression immunohistochemistry P53 and Matrix Metalloproteinase-9 (MMP-9) with tumor budding index in endometrial carcinoma. Results: The identification of 38 samples of endometrial carcinoma patients found that the most common age group was > 55 years, the most frequent distribution was low histopathological grading, low budding, and there was a significant correlation between the the expression of MMP-9 based on tumor budding. But no correlation between p53 expression and the tumor budding index and no correlation between p53 expression and mmp-9 in endometrial carcinoma.

matrix metalloproteinase-9

endometrial carcinoma

tumor budding

p53