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CD3 T LYMPHOCYTES COUNT OF APPARENTLY HEALTHY ADULT INDIVIDUALS IN EKPOMA, EDO STATE, NIGERIA

Volume: 99  ,  Issue: 1 , April    Published Date: 19 April 2022
Publisher Name: IJRP
Views: 51  ,  Download: 26 , Pages: 65 - 70    
DOI: 10.47119/IJRP100991420223073

Authors

# Author Name
1 Babatope, Isaac Olaniyi
2 Esumeh, Frederick Ikechukwu
3 Orhue, Philip Ogbeide
4 Amaechi, Rose Akubueziuka
5 Inojie, V.

Abstract

The CD3 protein complex is an important T cell marker. This study aimed at determining the CD3 T lymphocytes count of apparently healthy adult subjects in Ekpoma, Nigeria. A total of two hundred and sixty (260) apparently healthy subjects were randomly recruited for the study. The subjects were of the both sexes and belonged to 17 to 50 years of age range. Five millitres (5ml) of whole blood was collected from the antecubital vein and dispensed into Ethylene Diamine Tetraacetic Acid (EDTA) bottles. Flow cytometry was used to determine the absolute counts (cells/?l) of CD3+ T lymphocytes. The mean CD3 absolute count of the male subjects is 1445.88 cells/?l (Median 1460.00 cells/?l, Range 783.38-2222.70 cells/?l) compared to a mean CD3 absolute count of the female subjects – 1720.27 cells/?l (Median 1741.00 cells/?l, Range 686.20 – 2145 cells/?l). There is a significant higher difference (P<0.05) in the mean CD3 count of the female subjects compared to males. The overall (total) mean CD3 absolute count of the subjects studied was 1483.08 ± 381.55 cells/?l (Median 160.00 cells/?l, Range 788.73 – 2159.00 cells/?l). The age groups of 17-24 years, 25-32 years and 33-40 years showed a statistical significant difference (P<0.05) when the mean CD3 absolute counts of the female subjects were compared to males. However, the age group of 40 and above did not reveal any significant difference when both means were compared. In conclusion, the study has revealed that the mean CD3+ T lymphocyte count obtained in our study population is unique to the study and different from those of other populations and this will guide the management of immune-related disorders.

Keywords

  • Adult
  • Lymphocyte
  • CD3 count
  • Apparently Healthy
  • Adult