Background: In the adolescent phase is a period of growth and development that requires more energy and nutrients, resulting in lifestyle changes that can lead to obesity. Circuit weight training (CWT) is a circuit training that aims to increase muscle strength and muscle endurance. C-Reactive Protein (CRP) is an indicator of systemic inflammation and increases in obesity. Case: This study aimed to analyze the effect in obese male adolescents at SMAN 4 Surabaya. Subjects were 13 male adolescent age 14-18 years old, students of SMAN 4 Surabaya and obesity condition. Study subjects were intervened CWT 3 times in a week for 8 weeks. This study was conducted without calorie restriction. Analysis of the effect of CWT in CRP levels. Paired t test showed a significant CWT on CRP levels (p=0.00). Effect Size CWT very strong to CRP. Conclusion: CWT 3 times in a week for 8 weeks in obese male adolescents without calorie restriction can reduce CRP levels.