Background: Patients with end-stage renal disease (ESRD) have a high baseline level of systemic inflammation. Serum C-Reactive Protein is an inflammatory marker that is widely used because it is more affordable and available in most hospitals in developing countries. Patiens with ESRD tend to be less involved in physical activity when compared to sedentary patients in the same age group. The effect of intradialytic aerobic exercise on CRP levels has been widely studied, but the result studies about intradialytic aerobic exercise on CRP are still controversial. Objectives: To evaluate the effect of a 12-week intradialytic aerobic exercise program on serum CRP levels in ESRD at the Hemodialysis Installation of Dr. Soetomo Hospital, Surabaya Methods: The study was conducted from March to June 2021. Twenty-six ESRD patients divided into treatment and control groups were able to follow the study until the end. The treatment group did a low-intensity intradialytic exercise program for 12 weeks. Both groups were given education about inflammation in ESRD patients and continued drug therapy and diet as before. Serum CRP was checked before and after intervention. Results: There was a decrease in the mean CRP after the intervention, from 0.33 ? 0.33 to 0.27 ? 0.16 mg/dL but was no significant difference statistically (p=0.543) and the control group (p=0.08) and between the two groups (p=0.960). Conclusion: Intradialytic aerobic exercise has no effect on serum levels of C-reactive protein in end-stage renal disease patients

ESRD

intradialytic exercise

rehabilitation

rehabilitation

CRP