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The Effect of Vitamin E Administration in Topical Olive Oil and Metamizole Injection on Plasminogen Activator Inhibitor-1 (PAI-1) Peritoneal Fluid and Degree of Adhesion

Volume: 94  ,  Issue: 1 , February    Published Date: 01 February 2022
Publisher Name: IJRP
Views: 405  ,  Download: 331 , Pages: 1 - 10    
DOI: 10.47119/IJRP100941220222803

Authors

# Author Name
1 Wegig Perwiro Wibowo
2 Lulik Inggarwati
3 Widanto
4 Setyo Sugiharto
5 MS Niam

Abstract

Background and Purpose: Post-laparotomy adhesion is a problem for surgeons as well as patients. The purpose of this study was to establish a decrease in PAI-1 levels of peritoneal fluid, the degree of adhesion macroscopic and microscopically in male wistar rats subjected to ileum abrasion, between the combination of administration of vitamin E in topical olive oil and injection of Metamizole, single or unstained. Method: Laboratory experimental research. Using 24 male wistar rats which were subjected to ileum abrasion Re-laparotomy was performed 14 days later to see the PAI-1 level of the peritoneal fluid, the degree of adhesion macroscopic and the degree of adhesion microscopically. Dataanalysis by ANOVA, Kruskal Wallis, and Spearman test. Result: There was a significant difference in peritoneal fluid PAI-1 levels in the P0-P3 group (p=0.036), but there was no significant difference in peritoneal fluid PAI-1 levels between P0-P1 (p=0.761) and P0- P2 (p= 0.113). There was a significant difference in the P0-P3 group (p=0.005), but there was no significant difference between P0-P2 (p=0.403) and P0-P1 (p=0.187). Correlation test showed a significant correlation between PAI-1 levels of peritoneal fluid and the degree of macroscopic intraperitoneal adhesion with a large correlation of r = 0.750 (macroscopic) and macroscopic intraperitoneal adhesion with a large correlation of r = 0.729 (microscopic).Conclusion: Combination of vitamin E in topical olive oil with metamizole decrease in PAI-1 levels in peritoneal fluid, macroscopic and microscopic degree of adhesion.

Keywords

  • PAI1
  • Adhesion
  • Peritoneum
  • Vitamin E
  • Ileum abrasion
  • Laparotmy