Corona Virus Disease-19 (Covid-19) was declared a world pandemic which resulted in thousands of deaths in 216 countries around the world. There are 103 million cases of Covid-19 in the world, with 57.3 million patients are recovered and 2.24 million patients are died. Meanwhile, Indonesia has reported 1,099,687 cases, the highest in Southeast Asia, ahead of the Philippines. In this study, we focused directly on empirical studies and related keywords on the impact of COVID-19 on pregnancy and childbirth. Pregnant women have a higher risk of acquiring respiratory viral infections and severe pneumonia due to physiological changes in the immune and pulmonary systems. The effects of covid-19 on pregnancy and labor were studied and obtained contrary result, obtaining that it has no effect on the occurrence of miscarriages in the early first trimester, pregnant women are not at a higher risk of getting COVID-19 or suffering from more severe diseases than other adults, and no evidence on the ability of virus to be transmitted to the fetus during pregnancy or delivery. In addition, infants and young children are also known to have only mild forms of COVID-19. Meanwhile, other research obtained pro-results; including increased risk of obesity in early pregnancy, increased risk of membranes premature rupture by 11% and fetal distress by 14%, increased cases of delayed presentation of patients with ectopic pregnancy which causes increased morbidity and mortality. Furthermore, it also causes increased occurrence of hypercoagulability, increased maternal mortality with caesarean section by 58.3%, increased maternal mortality by vaginal delivery by 25% and premature infant mortality by 16.7%, perinatal mortality and morbidity, high risk of experiencing preeclampsia/eclampsia especially nullipara, severe infection. In addition, studies also discovered that covid-19 infection also increased the tendency of admission to intensive care unit, premature birth, risk of severe maternal complications, neonatal complications, miscarriage, stillbirth, fetal growth restriction, FIRS, neurosensory, developmental delay, and mental health improvement in pregnant women. In this case, the alternative management for handling COVID-19 during a pandemic in pregnant and maternal women is as follows: vaccines, embryonic mesenchymal stem cells, remdesivir, and convalescent plasma.