Helicobacter pylori infection occurs in about 50% of the world's population and most infections occur during childhood. This infection involves local inflammation in the stomach and a systemic humoral immune response that causes an increase in the number of neutrophils and a decrease in the number of lymphocytes. This study aims to determine the relationship between the value of the Neutrophil Lymphocyte Ratio in children with H. pylori infection and non-H. pylori infection. This cross-sectional analytical study involved 96 children aged 2-18 years who met the research criteria, blood was drawn and HPSA examination was performed, followed by bivariate analysis using the chi square test. The results showed that the subjects were 11.66 ? 3.69 years old, most of them were female (63.5%), with 51 children (53.1%) found to be positively infected with H. pylori. No significant relationship was found between the ratio of neutrophil lymphocytes and H. pylori infection (p = 0.509).