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THE ROLE OF KETOACID ANALOGS WITH DIETARY PROTEIN RESTRICTION IN CHRONIC KIDNEY DISEASE PATIENTS

Volume: 93  ,  Issue: 1 , January    Published Date: 21 January 2022
Publisher Name: IJRP
Views: 329  ,  Download: 271 , Pages: 178 - 188    
DOI: 10.47119/IJRP100931120222788

Authors

# Author Name
1 Ammar

Abstract

Introduction Chronic Kidney Disease (CKD) is abnormalities of kidney structure or function occurring for more than 3 months with implications for healths. The use of many interventions to delay the need for dialysis treatment in patients with CKD in the last stage, until recently, is a primary challenge. We need to remember that high protein intake leads to an increase in glomerular pressure and hyperfiltration that negatively influence on the kidneys. Objective This review article was created to provide knowledge to medical personnel about the importance of nutritional intervention with protein restriction in chronic kidney disease patients. In order to improve the quality of life related to delay the need for hemodialysis. Methods The Method of making this review article by summarizing from various scientific journal articles, most of which have been published in the last 10 years through BMC Nephrology, NEJM, IJBCP, BMJ Global Health, and J Am Soc Nephrology. Result One of the existing interventions, nowadays, is using the very low-protein diet intervention (0.3-0.4 g protein/kgBW/day). However, the impact of this dietary protein restriction can increase the risk of malnutrition and cachexia. The many research currently available show that safe protein requirement is needed for the body, such as giving ketoacid analogs. Ketoacid analogs can be used as a substitute for each amino acid without providing nitrogen products. Conclusion The very low-protein diet with ketoacid analogs has many benefits, for example, providing sufficient and optimal energy and nutrition to prevent malnutrition. Besides, the other benefits are the ability to reduce the uremic toxins, reduce proteinuria, increase the calcium and phosphate metabolism, repair the insulin sensitivity, improve the lipid profile, inhibiting the progress of CKD, and prevent cachexia.