Medicine, Health & Food

Medicine, Health & Food

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The Combination of High Calorie Diet and Moderate Interval Training Decreases Follicle Stimulating Hormone (FSH) Level In Rats

Volume: 91  ,  Issue: 1 , December    Published Date: 25 December 2021
Publisher Name: IJRP
Views: 61  ,  Download: 35 , Pages: 288 - 295    
DOI: 10.47119/IJRP1009111220212608


# Author Name
1 Sheila Sekar Mahadani
2 Lilik Herawati
3 Sri Ratna Dwiningsih


Background: Obesity can cause leptin and insulin resistance which will affect the production of GnRH and FSH. One of risks factor of obesity is high calorie intake chronicaly. Exercise plays a role in the regulation of blood calorie and body weight. However, the effect of exercise on subjects with a high-calorie diet on FSH is unknown. This study aims to determine the effect of a high calorie diet with moderate intensity interval training (MIIT) on FSH level in female rats. Method: Sample was 27 female rats (Rattus norvegicus) wistar strain were divided into 3 groups. The negative control group (standard diet), the positive control group (high calorie diet), and the MIIT group (high calorie diet and moderate-intensity exercise with intervals). Measurement of FSH using the ELISA method after treatment for 4 weeks. Result: Statistical analysis showed that there was a significant difference in FSH level with a value (p = 0.001). The mean FSH was 25.32 mIU/ml ± 7.89 in the negative control group, 19.71 mIU/ml ± 6.55 in the positive control group, and 12.12 mIU/ml ± 3.64 in the MIIT group. The decrease FSH in the positive control and MIIT group due to a high calorie diet caused insulin and leptin resistance which affected GnRH. Conclusion: Moderate interval training decreases the FSH level may due to the level of physical stress.


  • FSH;Exercise;High calorie diet;Healthy lifestyle