Background: Colorectal adenocarcinoma is a malignant epithelial tumour originating in the large bowel, showing glandular or mucinous differentiation. This tumour is the second most common cause of death due to cancer. The prognose can be predicted by evaluating the histological grading and tumour-infiltrating lymphocyte volume (TILV). TILV calculation is performed by multiplication of stromal TILs and tumour-stroma ratio (TSR). TILV score ?1300 have significantly better prognosis. Methods: This is an analytical study with cross sectional approach on 32 resection specimens from the patients diagnosed as colorectal adenocarcinoma stained with Haematoxylin & Eosin. The statistical analysis was performed by using Spearman rank correlation to analyse the association of TILV score and histological grading of colorectal adenocarcinoma. Results: There were 32 sample of colorectal adenocarcinoma observed and the number of the low grade was greater than the high grade. Tumour with lower grade had higher stromal TILs and lower proportion of stroma. Colorectal adenocarcinoma with higher grade had lower TILV score. The TILV score showed significantly strong correlation with histological grading of colorectal adenocarcinoma.

colorectal adenocarcinoma

stromal TILs

TSR

TILV