The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), launched the COVID-19 pandemic putting the majority of the countries on lockdown. As vaccine development pursues, the need to analyze the determinants of vaccine hesitancy among Filipinos are paramount in order to address poor vaccine uptake and boost vaccine acceptability. This study is a descriptive-comparative study that compares the stand of select Manila residents? pro-vaxxers and anti-vaxxers and the factors that affect their perspective on COVID-19 vaccination. A survey questionnaire was disseminated online to respondents who are qualified based on the following criteria: Filipinos ages 18 to 65 years old who are Manila City residents, at least secondary school graduates, are willing to be involved in the study, and have not contracted the virus nor received a vaccination for it. Out of the 189 participants of the study, 180 of which were classified as pro-vaxxers and 9 as anti-vaxxers. After analysis of data, the respondents, in general, agree that Safety and Effectivity (x=3.08), Trust (x=2.88) and Social (x=2.44) factors positively affect their COVID-19 perspective while Experiences (x=1.66), Beliefs (x=1.74), and Financial (x=2.45) factors were less likely to affect their perspectives. An unpaired t-test was also used on the factors to determine the significant difference in the perspectives of the two groups, whose results are as follows: Safety and Effectivity (p = 0.650), Trust (p = 0.033), Social (p = 0.003), Experiences (p = 0.325), Beliefs (x = 0.029), and Financial (p = 0.050). Four of these factors namely Trust, Social, Beliefs, and Financial were found to have a significant difference (p 0.05).

COVID-19

Anti-vaxxers

Pro-vaxxers

Pandemic

COVID-19

Vaccines

Vaccine Hesitancy

Perspective

Philippines