Objective: In this study, the researchers were interested in seeing the relationship between smoking and disc degeneration as seen in the histology of mouse intervertebral discs using experimental studies. Methods : This type of research is experimental research. White rats were divided into 3 groups, namely the first group was euthanized before the exposure to cigarette smoke (n = 5), the second group was euthanized on the 14th day after exposure to cigarette smoke (n = 5), and the third group was euthanized on the 28th day after exposure. cigarette smoke (n = 5). At the appointed time, a sample is taken for histological examination of the vertebral discs. Result: Based on statistical results, there were significant changes in Annulus fibrosus in mice exposed to cigarettes on day 14 and day 28. Conclusions: There was a significant change in the histopathological features of the vertebral disc after exposure to cigarette smoke. This proves that cigarette smoke can cause lower back pain and can be used as an educational material for the community. Further research is needed to deepen this causal relationship.

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