Background: Hepatitis B infection during pregnancy is still a unique problem for the mother and her fetus. These include the effects of hepatitis B on maternal and fetal health, the effects of pregnancy on hepatitis B infection in pregnancy, treatment of hepatitis B during pregnancy and prevention of mother-to-child transmission. Case description: A young woman was referred for jaundice in pregnancy. Physical examination revealed icteric sclera in both eyes. Laboratory tests show increased liver function as well as bilirubin. for testing for hepatitis B reactive. The patient received lamivudine therapy and cesarean section therapy. Conclusion: Management and treatment of chronic hepatitis B is difficult because of the variable course of the disease. It is even more complex in pregnant patients. Joint decision-making between physicians and female patients regarding the timing of initiation of antiviral therapy is critical to improving outcomes. Optimal initiation of antiviral therapy in the general population depends on the histologic degree of inflammation and fibrosis. We now know that post-partum HBIG and vaccination for infants born to chronically infected mothers can be ineffective in preventing MTCT to regulate increased maternal HBV viremia.