This study aimed to explore the effectiveness of learning activity using indigenous material in physics at Antipolo City Senior High school. The use of indigenous materials in learning activities will serve as substitute materials for conducting laboratory activities of students at home during this pandemic. The respondents of this study are the grade 12 students of Antipolo City Senior High School during the school year 2020-2021. A questionnaire was administered in two sections of grade 12 STEM students. The findings of this study show that the designed learning activities in Physics using locally, ready and available materials were found very suitable and effective as a substitute for laboratory equipment used in school amidst this pandemic. The newly designed learning activities using indigenous materials are highly recommended for the use of the Senior High School students who will take a Physics course with or without pandemic. Moreover, Science teachers are encouraged to become resourceful in designing more learning activities or laboratory experiments with the utilization of local or indigenous materials not only as a substitute for science equipment but to tap the availability of the local community?s resources for producing its own genuine locally made products or science equipment.