Background: Colorectal carcinoma is a malignant epithelial tumor originating from the large intestine (colon and rectum) which shows differentiation of glands and mucin, accompanied by invasion between the stroma of the mucous muscularis layer to the submucosa layer. World Health Organitation (WHO) recommends reporting several histopathological features in colorectal carcinoma related to the prognosis of the patient. Methods: This study is a descriptive study with a cross sectional approach. There were 60 samples diagnosed histopathologically as adenocarcinoma colorectal from paraffin block at RSUP H. Adam Malik Medan in 2019-2020. Data regarding age, sex, tumor location, and clinical stage were obtained from medical records. Slaid reviews were performed, histopathologic subtypes, grade, Lymphatic invasion, Intra Mural Vascular Invasion (IMVI), Extra Mural Vascular Invasion (EMVI), Perineural Invasion (PNI), tumor budding, TILs, and depth of invasion (T) were determined. Results: The mean age of the patients was 51.9 years with a minimum age of 22 years and a maximum of 83 years, the most common age group was 50-59 years, men were found more than women, and the location of the tumor was most found in the rectum. The most histopathologic subtypes were adenocarcinoma NOS, with common grade was low grade (73.3%). Lymphatic invasion was found in 22 cases (36.7%), most vascular invasion found was EMVI (35%), PNI was found in 16 cases (26.7%), most tumor budding were low budding, most frequent grade of TILs was moderate, and most clinical stage is stage II.

Histomorphology

adenocarcinoma colorectal