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The Relationship between CRP Levels and Gastritis in Children with or without Helicobacter pylori Infection

Volume: 79  ,  Issue: 1 , June    Published Date: 06 July 2021
Publisher Name: IJRP
Views: 56  ,  Download: 18 , Pages: 161 - 169    
DOI: 10.47119/IJRP100791620212041

Authors

# Author Name
1 M. Azhariy Daulay
2 Supriatmo
3 Aridamuriany D. Lubis
4 Isti Fujiati
5 Oke Rina Ramayani
6 Tina C L Tobing

Abstract

Background: Helicobacter pylori infection is the cause of most gastritis in the world population. In establish and determining the severity of gastiritis, a combination of clinical symptoms, physical examination, and support laboratories is needed. Gastritis is a chronic inflammation which can increase inflammatory markers, including CRP. Investigation such as CRP, can measure the level of inflammation objectively, and can help to evaluate clinical patient. Previous studies have shown that H.pylori infection causes increased CRP concentrations. Methods: This study is a cross sectional of data on children who are treated in the Gastrohepatology division aged 2-18 years old, that have been diagnosed with gastritis through endoscopic examination with CLO measurements, and have CRP level, according to inclusion and exclusion criteria. The data with gastritis were further divided into positive H.pylori and negative H.pylori. The caracteristics of children and parents were recorded. Result: This study involved 62 data children who met the inclusion and exclusion criteria. From the CLO examination, there were 30 children with positive H.pylori and 32 children with negative H.pylori. the dominant clinical symptom in both groups was recurrent abdominal pain, but there was no significant difference between them. The mean CRP value obtained in the positive H.pylori group was 36,78, while in the negative H.pylori group it was 11,73. There were significant differences in CRP valus between them (p<0,001). Conclusion: There was an association between CRP level in pediatric gastritis with H.pylori infection compared to without H.pylori infection. Keyword: CRP, Helicobacter pylori, Gastritis in children