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Apparent Diffusion Coefficient and Time Intensity Curve Values from Dynamic Contrast Enhancement (DCE) MRI in Osteosarcoma Histopathological Subtypes

Volume: 79  ,  Issue: 1 , June    Published Date: 23 June 2021
Publisher Name: IJRP
Views: 66  ,  Download: 25 , Pages: 22 - 29    
DOI: 10.47119/IJRP100791620212001


# Author Name
1 Bagus Novariyanto
2 Rosy Setiawati
3 Paulus Rahardjo
4 Sjahjenny Mustokoweni
5 Giuseppe Guglielmi


Background: According to WHO criteria osteosarcoma consists of various histopathological subtypes. Magnetic resonance imaging (MRI) is an important imaging modality for preoperative and post-treatment evaluations of osteosarcoma. Dynamic Contrast Enhancement Magnetic Resonance Imaging (DCE-MRI) study is used to determine Apparent Diffusion Coefficient (ADC) value and Time Intensity Curve (TIC). This study aims to describe Apparent Diffusion Coefficient value and Time Intensity Curve in osteosarcoma of histopathological subtypes. Methods: This study was a retrospective with observational analysis on osteosarcoma patients. Data were taken from osteosarcoma patient's medical record and result of Dynamic Contrast Enhancement in 3 Tesla MRI examination. For ADC we placed the region of interest (ROI) in three places to get ADC value. There were six ROIs from two musculoskeletal radiologist consultants that were averaged. TIC curve were conducted in these ROI and the highest type is pickup. The data was analyzed using SPSS 21 software. Result: There were 43 samples. Interpretation was conducted by placing three regions of interest (ROI) to determine Apparent Diffusion Coefficient (ADC) value, which was conducted by two musculoskeletal radiologist consultants. Time Intensity Curve (TIC) type was analyzed from DCE-MRI study result. There were 67.4% male and 32.6% female samples, where most samples belonged to 11-20 years group (53.5%). The most common osteosarcoma locations were femur (48.8%) and tibia (41.8%). Osteosarcoma mean ADC value in this study was (1.031x10-3?0.31mm2/s), where the highest value was found in chondroblastic subtype (1.470 x10-3?0.31 mm2/s) followed by fibroblastic subtpe (1.003x10-3?0.24mm2/s) and osteoblastic subtype (0.984x10-3?0.23mm2/s). Osteosarcoma TIC types found in this study were type 3 and type 4, with predominantly type 3 for all subtypes. Conclusion: ADC value may improve diagnosis accuracy in osteosarcoma cases. Time Intensity Curve type may also help analysis to diagnose osteosarcoma.


  • apparent diffusion coeffisien
  • Osteosarcoma
  • Time Intensity Curve
  • Osteosarcoma Histopathology