Medicine, Health & Food

Medicine, Health & Food

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Effect of High Intensity Interval Training with Changes in Inclination to Irisin of Men with Overweight and Obesity

Volume: 77  ,  Issue: 1 , May    Published Date: 25 May 2021
Publisher Name: IJRP
Views: 74  ,  Download: 30 , Pages: 38 - 42    
DOI: 10.47119/IJRP100771520211934


# Author Name
1 Natanael Sinulingga
2 Sri Mardjiati Mei Wulan
3 Indrayuni Lukitra Wardani
4 Meisy Andriana
5 Lydia Arfianti
6 Damayanti Tinduh


Background: As the prevalence is rising worldwide, overweight and obesity has become a major public health issue. Overweight and obese individuals had excess energy accumulation in the form of adipocyte tissue. High-intensity interval training (HIIT) is proposed as an exercise therapy option in weight reduction. Irisin, a myokine released after exercise, was thought to play a major role in weight reduction by browning adipocyte tissue. Therefore, this study aims to see how HIIT with changes in inclination affects irisin serum levels in overweight and obese men. Methods: A randomized-controlled trial was conducted in rehabilitation outpatient clinic of Dr. Soetomo General Academic Hospital. Twenty-two subjects with overweight or obesity who meet research criteria were randomly allocated into intervention and control group. Intervention group received HIIT using treadmill (HR rest + 80-90% HR reserve) with inclination changes for 30 minutes (preceded by warming up and ending with cooling, 5 minutes each), 3 times a week, for 4 weeks. Control group received no intervention. Measurement of irisin serum levels in the intervention group was carried out before exercise, 30 minutes after first exercise, 30 minutes after last exercise, and one day after 4 weeks of exercise, while in the control group was carried out before and on one day after 4 weeks. Results: No differences of body height, body weight, BMI, and VO2Max between groups (p<0.05). Subjects in control group are older than intervention group (34.82±3.09 vs 30.36±2.58, p = 0.002). Irisin serum levels was reduced 30 minutes after the first exercise (p = 0.017) and after 4-weeks exercise program (p = 0.006). Between groups comparison showed no difference in changes in irisin serum levels after 4 weeks between the two groups (p = 0.182), however glass delta mean effect size shows medium result (Glass's delta = 0.50). Conclusion: A significant reduction in irisin serum level may be correlated with reduction of adipose tissues and improvement of homeostasis after HIIT. High intensity interval training can be proposed as an exercise therapy option to support weight reduction in men with overweight and obesity. It is necessary to do further research on HIIT with a larger number of samples, longer time, group training and combined with other exercise such as resistance and flexibility exercises.


  • Indonesia
  • adipose tissue
  • rehabilitation
  • exercise therapy
  • high-intensity interval training