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Neutrophils-Lymphocytes Ratio (NLR) and Platelet-Lymphocytes Ratio (PLR) as Prognostic Factor of Osteosarcoma Patients at H. Adam Malik Hospital 2013 – 2018

Volume: 76  ,  Issue: 1 , May    Published Date: 09 May 2021
Publisher Name: IJRP
Views: 88  ,  Download: 36 , Pages: 1 - 10    
DOI: 10.47119/IJRP100761520211909

Authors

# Author Name
1 Stefan Andhika
2 Pranajaya Dharma Kadar
3 Muhammad Hidayat Siregar

Abstract

Abstract: Introduction: Several systemic markers are used to predict the prognosis of several malignant tumours, but no study has been done to observe the correlation between inflammatory markers and 2-year survival rate of osteosarcoma patients. The purpose of this study is to identify the correlation between NLR and PLR with osteosarcoma prognosis and the patient’s 2-year survival rate. Methodology: This is a retrospective study with a diagnostic research design. Data of patients who were diagnosed with osteosarcoma from January 2013 – December 2018 in Haji Adam Malik Hospital is collected from their medical record or through by-phone interview to assess the patient’s management history and progression post-treatment. Result : A total of 40 samples were included in this study. Using the Kaplan-Meier graph, 2-year survival rate was analysed according to age, gender, tumour location, metastatic status, previous treatment, NLR, and PLR value. Only 1 subject has a survival rate of more than 2 years. In relation to NLR and PLR, it is shown that subjects with lower values have higher survival rate as compared to subjects with higher values. Discussion : ROC analysis was performed to see the incidence of osteosarcoma by observing AUC determine its significance. The AUC NLR value for osteosarcoma (0.972, p-value 0.002, 95% CI, 0.919-1000) was obtained, and the NLR cut-off value was 1.41 (sensitivity 75%; specificity 97%). The AUC PLR value for osteosarcoma (0.944, p-value 0.004, 95% CI 0.871 - 1,000) and cutoff value of 97.477 (sensitivity 75%, specificity 89%) were obtained. The 2-year survival rate of osteosarcoma patients was higher, namely 29 months in subjects with low NLR values, 13 months in subjects with high NLR, 17 months in subjects with low PLR values , and 14 months in subjects with high PLR values.

Keywords

  • Osteosarcoma
  • Neutrophil
  • lymphocyte
  • platelet