Medicine, Health & Food

Medicine, Health & Food

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Application of histochemistry AgNORs in diagnosing benign lesion, premalignant and malignant prostate tissue

Volume: 73  ,  Issue: 1 , March    Published Date: 25 March 2021
Publisher Name: IJRP
Views: 60  ,  Download: 23
DOI: 10.47119/IJRP100731320201801


# Author Name
1 Lidya Imelda Laksmi
2 Fauriski Febrian Prapiska
3 T. Ibnu Alferraly


Objective: Argyrophilic nucleolar organizer regions (AgNORs) count has been suggested as an objective method in differentiating of various non neoplastic lesions of the prostate. Material and Methods: This study was done on archival paraffin block consisting of 6 cases of each, benign, premalignant, and malignant lesions of the prostate. All specimens were studied and evaluated with Haematoxylyn and Eosin followed by AgNORs histochemistry staining and its expression was determined by counting AgNORs dot per nuclei in 100 nuclei using a 100x oil immersion lens. Results: The results showed a linear increasing trend of mean mAgNOR count according to prostatic lesion (benign to malignant). However, this is not statistically significance as the p-value > 0,05 (p- value=0,516). Conclusion: Based on this study, AgNOR cannot be use to determine prostatic lesion behavior. Futher study with larger samples should be done to get significant result.


  • Premalignant
  • prostate
  • AgNORs
  • benign
  • malignant