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Effectiveness of Probiotic on Eradication Helicobacter Pylori Gastritis in Children

Volume: 62  ,  Issue: 1 , October    Published Date: 06 November 2020
Publisher Name: IJRP
Views: 384  ,  Download: 266 , Pages: 199 - 208    
DOI: 10.47119/IJRP1006211020201481

Authors

# Author Name
1 Masitah Nasution
2 Supriatmo
3 Aridamuriany D Lubis
4 Gontar A Siregar
5 Chairul Yoel
6 Rizky Adriansyah

Abstract

Background: Helicobacter pylori (H. pylori) is one of the causes of intestinal and gastric ulcers or one of the factors causing gastric malignancy. The prevalence of H. pylori infection is more than 80% in developing countries. Probiotics provide beneficial effects on the host’s health when administered in an adequate amount. Lactobacillus and Bifidobacteria are the most commonly used as probiotics. H.pylori colonization is interfered with by regular ingestion of L. acidophilus, and the urea breath test values decreased by approximately 10% four weeks after treatment. Objective: To assess the effectiveness of probiotic in eradication of H. pylori gastritis in children along with triple therapy Methods: This clinical trial design in children with H. pylori gastritis in a network hospital in Medan. Sampling was carried out from August 2019 - April 2020 with randomization techniques and double-blind in children suffering from H. pylori gastritis based on history, physical examination, H. pylori stool antigen (HpSA) test and endoscopy. Mc Nemar test analysis was performed to assess the difference effectiveness of drugs in the two groups. Result: From 33 children who received probiotics 31 children eradicated and from 31 children who did not receive probiotics, 29 children were eradicated. From 33 children who received probiotics, 6 children had side effects. From 31 children who did not receive probiotics, 22 children had side effects such as nausea/vomiting, abdominal pain, and diarrhea. There was no significant difference between probiotics and triple therapy with only triple therapy (p = 1,000). However, there was a significant difference in reducing the side effects of nausea/vomiting and diarrhea in the probiotic group (p = 0.015). Conclusion: There were no significant differences between administering probiotics plus triple therapy with triple therapy only to eradicate H. pylori gastritis in children. However, there were significant differences in the probiotic group in reducing the symptoms of side effects.

Keywords

  • children
  • gastritis
  • helicobacter pylori
  • probiotics
  • triple therapy