Stroke is one of leading cause of mortality. Stroke increases 5-8 times the risk of cognitive impairment. The presence of strategic infarct locations and white matter changes were reported to be associated with cognitive impairment on ischemic stroke. This study aims to describe the characteristic of cognitive function of cerebral infarction patient in strategic and non-strategic locations; and white matter changes. This is descriptive study with retrospective design. Data of ischemic stroke patient at the Diagnostic Radiology Installation of Dr. Soetomo Surabaya during January - February 2020, were collected. Blennow scale was used to evaluate white matter changes, based on MSCT Scan. Degree of cognitive function assessed with MoCA-INA score. Total of 49 ischemic stroke patients, mostly in the age group of 51-60 and >60 years old (38,8%), male (59,2%), with strategic infarct locations (75,5%), and Blennow scale 2-3 (55,1%). Most of the subjects have decreased cognitive function (83.7%). Subjects who experienced cognitive dysfunction were mostly found in the age group 41 - 50 and >60 years old (34.7%). Cognitive impairment were mostly found in male patients (46.9%), with strategic infarct locations (69.4%), and with Blennow scale 2 ? 3 (51%). Cognitive function in patient with strategic infarct locations, and white matter changes, mostly impaired.

cerebral infarction; cognitive function; white matter changes