The study was aimed to determine Time Intensity Curve (TIC) type and % slope value on Dynamic Contrast Enhancement Magnetic Resonance Imaging (DCE-MRI) examination technique to differentiate between benign and malignant bone lesion. The study was done on December 2018 to July 2019 with retrospective cross sectional analytic study. The samples were bone lesion patients which was examined with Dynamic Contrast Enhancement on 3T MRI. The sample size were 15 subjects, consisted of 8 (53.3%) males and 7 (46.7%) females. The age range of subjects was 13 to 75 years old (38,20 ? 20.49 y.o). Patients with malignant bone lesion were 9 (60%) people and benign bone lesion were 6 (40%) people. DCE-MRI could assess tissue vascularization and perfusion based on TIC. In this study, benign bone lesion showed TIC type 2 and 3, while malignant bone lesion mostly showed TIC type 4, with mean %slope value of malignant bone lesion was 83,66 ? 75,34 % and for benign bone lesion was 9,82 ? 5,94 % with cut-off value for malignancy of >26,70%/m. The mean %slope value differential for malignant and benign bone lesion was statistically significant (p<0.05). TIC examination had sensitivity of 75% and specificity of 100% in differentiating malignant and benign bone lesion. The difference in pattern type and mean %slope value of Time Intensity Curve (TIC) between benign and malignant bone lesion showed that DCE-MRI has important role in differentiating between benign and malignant bone lesion