Agriculture is the sole source of livelihood for the majority of Ethiopian.  Ethiopia endowed with huge potential for agricultural development and cereal crops like maize are widely cultivated across a range of environmental conditions. The general objective of this study was to examine the determinants of production of maize in Yeki Woreda, Sheka zone Southwest Ethiopia. The data for this study obtained from Yeki Woreda agricultural office. Different statistical methodologies used to fit collected data like descriptive statistics, Multiple Linear regression model with dummy variables and Analysis of variance (ANOVA). The goodness of fit test like coefficient of determination and adjusted coefficient of determination used to check the effectiveness of the model. In addition, the assumptions of linear regression model and assumption of ANOVA checked. The results of this study revealed that DAP, Urea, farm size in hectare and number of participant had statistical significant relationship with the production of maize. Giving attention to those factors may increase the production of maize. Therefore, all concerned body should give due emphasis to the identified factors to increase maize production.