Medicine, Health & Food

Medicine, Health & Food

Cytomorphology of Adenocarcinoma Metastasis in Pleural Effusion Fluid at the H. Adam Malik Central General Hospital Medan in 2015-2017

Pages: 7  ,  Volume: 26  ,  Issue: 1 , April   2018
Received: 22 Apr 2019  ,  Published: 25 April 2019
Views: 67  ,  Download: 36

Authors

# Author Name
1 Irmayani
2 Soekimin
3 Chrestella jessy

Abstract

ABSTRACT

Background: Lung cancer most often causes malignant pleural effusion and the most common type is adenocarcinoma. Metastastasis of breast, gastrointestinal and genitalia tumors is also a frequent cause of pleural effusion through lymphatic spread and it is important to observe the dominant cytomorphological picture of pleural effusion in adenocarcinoma metastasis.

Objective: To determine the cytomorphology of adenocarcinoma metastasis in pleural effusion fluid

Material and Methods: Cytomorphological observations were performed on pleural effusion cytology slides consisting of 36 samples to determine the dominant cytomorphology. All characteristic data are obtained through medical records and pathology archives. Statistical analysis is descriptive with cross sectional approach.

Result: Most of the patient were diagnosed at the age of 55-64 years with female dominance and the origin of all metastases from lung adenocarcinoma. The most common cytomorphology of  long adenocarcinoma metastasis in pleural effusion fluid is the hyperchromatic nucleus, pleomorphic nucleus and increased N/C ratio and subsequent sequences are irregular core membrane, macronucleoli, acinar, perinuclear vacuolation, cell ball, binucleated, uniform cell population, eccentric nucleus, papillary formation, berry countour and the least is cell in cell.

Conclusion: The results of this study have various similarities with previous studies, but further examination and research are needed for better results.

Keywords: Pleura effusion, adenocarcinoma, pulmonary adenocarcinoma, cytomorphology

Keywords

References

  •  
  1. Taeyun. Gambaran efusi pleura pada pasien karsinoma paru di RSUP M. Djamil Padang pada tahun 2010-2014. Universitas Andalas. Padang; 2014
  2. Rezeki S, Arbaningsih. Sensitivitas dan spesifitas pemeriksaan CEA cairan pleura dalam diagnosis efusi pleura ganas karena kanker paru. USU; 2011
  3. Shahruddin E, Hudoyo A, Arif N. Efusi pleura ganas pada kanker paru. FK-UI, RS Persahabatan, Jakarta; 2009
  4. Kementrian Kesehatan Republik Indonesia: Pedoman Nasional Pelayanan Kedokteran; Kanker Paru, Jakarata; 2017
  5. Rodriguez FE, Dacic S, Pantanow L, khalbuss V, Monaco E. Cytopathology of Pulmonary Adenocarcinoma with a Single Histological Pattern Using the Proposed International Association for the Study of Lung Cancer/American Thoracic Society/European Respiratory Society (IASLC/ATS/ERS) Classification. Online library; 2015
  6. Travis WD, Noguchi M, Yatabe Y, Brambila E, Nicholsan AG, Aisner SC et al. Adenokarsinma. In: Travis WD, Brambilla E, Burke PA, Marx A, Nicholsan GA, eds. WHO Classificaation of Tumours of the Lung, Pleura, Thymus and Heart. Lyon: IARC; 2015. p.34-48
  7. Yovi I, Anggraini, Ammalia S. Hubungan karakteristik dan etiologi efusi pleura di RSUD Arifin Ahmad Pekanbaru. SMF/KJF pulomonologi, FK Universitas Riau, Riau. J respir indo Vol. 37 N0.2. 2017
  8. Riquet M, baduol C, Limpec LF, Marialothe F, Souilamas R, Pierre J, Danel C. Visceral pleura invasion and pleura lavage tumor cytology by lung cancer : A prospestive appraisal. Aann thorac surg 2013;75;353-5
  9. Ali SZ, Yang G. Lung and Mediastinum Cytohistology. Cambridge University Press. 2012. p.169
  10. Melamed MR. Tumors of the Lung: conventional cytology and aspiration biopsy In: Koss LG, Melamed MR, eds. Koss’ Diagnostic Cytology and Its Histopathologic Bases. Vol. II. 5th ed. Lipincott William & Wilkins; 2016. p.644-83
  11. Segal A, Frost AF, Silverman FJ. Lung, Chest wall and pleura. In: Orell RS, Sterrett FG, eds. Orell & Sterrett’s Fine Needle Aspiration Cytology. 5th ed. Australia; 2012. p. 210-53
  12. Kho-Duffin J, Tao L-C, Cramen H, et al. Cytologic diagnosis of malignant mesothelioma, with particular emphasis on the epithelial non cohesive cell type. Diagn Cytopathol 2008;20:57–62.
  13. Erika R, Sanja D, Liron P, Walid E, Sara E. Cytopathology of Pulmonary Adenocarcinomas with a Single Histological Pattern. 2013. Volume 2, Supplement, p.55
  14. Ali SZ, Yang G. Lung and Mediastinum Cytohistology. Cambridge University Press. 2012. p.169