Solar refrigeration system has the potential to improve the quality of life of people who live in area of insufficient electricity. This paper is about the study and analysis of solar powered vapour compression refrigeration system to keep vaccine placed at rural area in the temperature range between 2 to 8 °C without grid. The cooling load to be met by the photovoltaic generator depends on ambient air temperature, the special condition of refrigerator to preserve vaccine at this temperature range and size of the cooling space and matching condition between the photovoltaic module and compressor’s power. This paper presents the calculation of the heat gain through the refrigerator wall and heat absorbed by the vaccine bottle based on ambient air temperature of the hottest months (March, April, and May). And then, the performance analysis of refrigeration system is represented by using experimental result data. The photovoltaic generator and vapour compression refrigerator are matched by DC inverter. The relationship of outside temperature of surrounding and power of photovoltaic module are deal by MATLAB software.