Medicine, Health & Food

Medicine, Health & Food

Effect of Using Valproate Acid Monotherapy on Color Perception of Children with Epilepsy in Universitas Sumatera Utara Hospital and Network Hospital

Pages: 8  ,  Volume: 18  ,  Issue: 1 , December   2018
Received: 16 Dec 2018  ,  Published: 23 December 2018
Views: 87  ,  Download: 55


# Author Name
1 Barii Hafidh Pramono
2 Aryani Atiyatul Amra
3 Fithria Aldy
4 Yazid Dimyati



The medical management for epilepsy sufferers is to control generated seizures therefore not repeatedly occur using long-term anti-seizure medicines. Long-term treatment of epilepsy will potentially cause side effects, one of which is often used is valproate acid (VPA). It is known that VPA has ocular effects such as color perception disorders.


This study was prospective, observational analytic using cross sectional study method. Subjects were girl patients with a diagnosis of pediatric epilepsy who received VPA monotherapy at Universitas Sumatera Utara Hospital and Network Hospital.


From 35 subjects with average age of 11 years old, using wilcoxon signed rank test, found the significance value 0,0001* therefore there was effect significantly on subjects on color perception disorder. The most type of color perception disorders found was tritan with slightly severity. Based on the duration of VPA, using fisher's exact test, the significance value was 0.021* so that there was a significant effect of color perception disorders. Based on the doses of VPA, using fisher's exact test, the significance value was 0.334 so that there was no effect between the dose of VPA and color perception disorder.


There was a significant effect between the duration of VPA used on color perception disorders, there was no significant effect between the dose of VPA on color perception disorders, and the most type of color perception disorders was tritan.

Keywords : Valproate acid, Epilepsy, Color Perception


  • effect
  • impact
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