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Mucoadhesive system to enhance drug activity containing Flurbiprofen as model drug

Volume: 59  ,  Issue: 1 , August    Published Date: 09 September 2020
Publisher Name: IJRP
Views: 50  ,  Download: 15
DOI: 10.47119/IJRP100591820201377

Authors

# Author Name
1 Waqar siddique
2 Farhan Asghar
3 Sarfraz Ahmad
4 Maria Gul
5 Tangina Malik

Abstract

Abstract: To develop bucaal mucoadhesive drug delivery system which retains and diffuses drug for prolong period of time. Flurbiprofen due to its use in elderly patients for the symptoms of joint pain as well as in dental issues, Aim is to facilitate patients by prolonging the delivery of drug substance by formulating mucoadhseive system. Mucoadhesive polymers like HPMC, Sodium carboxy methyl cellulose and carbopol were used to formulate the tablets by using direct compression method. Characterization of the tablets was done to confirm their usability. Results indicate that tablets prepared by employing carbopol depict better mucoadhesive as well as better sustained release buccal mucoadhesive tablets.

Keywords

  • Buccal resistance time
  • Dry granulation technique
  • Mucoadhesive drug delivery system
  • in-vitro characterization
  • Mucoretentive
  • References

    References

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