Background: Erectile dysfunction (ED) is defined as the inability to obtain and maintain a penile erection adequately for sexual intercourse consistently for a period of 3 months. Current treatments for erectile dysfunction were aimed on a temporary basis and do not have a permanent effect on disruption of the endothelium or homeostasis of the penile tissue. The stem cell secretome is a bioactive substance that has active components, namely VEGF and NGF, which are known to prevent ED through their pro-angiogenic and neuro- regenerative/neurotrophic properties. Objective: The objective of this study was to analyze the effect of secretome of umbilical cord mesenchymal stem cell (UC-MSCs) on intima-media thickness (IMT) of the cavernous arteries in patients with severe erectile dysfunction non-respond to sildenafil. Method: The research used a pre-post-test design which was carried out from April to May 2024. Evaluation of the IMT using ultrasound on the flaccid state, without injection of erectile agent, examined before and one month after intra- cavernous injection the secretome of UC-MSc. Results: Seven patients aged 54-65 years were obtained who met the inclusion and exclusion criteria. There are statistically significant changes of IMT on the proximal and mid part of the right side of corpus cavernosum following the intervention, but there are not statistically significant changes on the other part of the corpus cavernosum. Conclusion : the dominant IMT changes were not statistically significant, namely on the right distal side and left proximal-mid-distal, but they were statistically significant on the right proximal-mid side.

Erectile dysfunction

secretome

intima-media thickness